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Judges in The Hague upheld the Bosnian Serb leader's conviction in connection with the 1995 Srebrenica massacre that claimed the lives of 8,000 Muslim men and boys.
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Mladic's conviction "serves as a reminder of the evil one man can do with an army at his command," writes NPR's Tom Gjelten, who covered the war in Bosnia in the 1990s.
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The International Criminal Tribunal for the former Yugoslavia found the former Bosnian Serb general guilty of multiple counts of crimes against humanity and one count of genocide.